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Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity
Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli.
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The Minister For Health&Children Commences The Outstanding Sections Of The Pharmacy Act 2007 Dealing With Complaints, Inquires And Discipline, Ireland
The Minister for Health and Children, Mary Harney TD, announced the commencement of the outstanding Sections of the Pharmacy Act 2007 to provide for the introduction of a Complaints, Inquires and Discipline regime for pharmacists and pharmacy businesses. Also included are Sections 63 and 64 of the Act, which relate to the prohibition of certain economic relationships between pharmacists or pharmacies and medical practitioners, or medical practices.
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Repeated Stress Signals Made In Cells With Metabolism-Associated Disease Encourage The Growth Of Invading Bacteria
Mitochondrial diseases disrupt the power generating machinery within cells and increase a person"s susceptibility to bacterial infection, particularly in the lungs or respiratory tract. A new study published in Disease Models & Mechanisms (DMM), shows that infection with the pneumonia causing bacteria Legionella, is facilitated by an increased amount of a signaling protein that is associated with mitochondrial disease.
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White House Officials Used Twitter, Ashton Kutcher To Promote HIV Testing Day

The White House sought the help of actor Ashton Kutcher to promote National HIV Testing Day on June 27, through his Twitter page, Politico reports. Kutcher has over 2.5 million followers on Twitter, where he recently posted a link to a White House blog post and video commemorating the day. Reid Cherlin, White House assistant press secretary, said, "As technology impacts how and where people are communicating online, we are constantly looking for new ways to engage with the public," adding, "Our efforts to promote National HIV Testing Day included participation from popular users of Twitter, as well as broad social media engagement by agencies across the government." The White House also used Twitter to help connect people to HIV testing sites (Gavin, 6/29). This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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