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Agendia Supports Genentech's Citizen's Petition Urging FDA To Hold In-Vitro Diagnostic Tests To One Set Of Scientific And Regulatory Standards
Agendia, a world leader in molecular cancer diagnostics, announced
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More Than 9 In 10 Primary Care Physicians Say U.S. Health Care System Should Place Greater Emphasis On Nutrition To Manage Chronic Disease
Ninety-six percent of primary care physicians believe the nation"s health care system should place more emphasis on nutrition to treat and manage chronic disease, according to a new survey released today. However, only 12 percent believe physicians currently pay significant attention to nutrition in the context of chronic disease.
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Report On Contaminated Drinking Water At Camp Lejeune
Two chemicals - trichloroethylene (TCE) and tetrachloroethylene (PCE) - found to have contaminated drinking water at Marine Corps Base Camp Lejeune from the 1950s to 1985 have been linked to certain diseases and disorders, including various cancers. A new report from the National Research Council, Contaminated Water Supplies at Camp Lejeune - Assessing Potential Health Effects, reviews scientific evidence about the potential adverse health effects that could occur after exposure to TCE, PCE, and other contaminants; recommends the usefulness of conducting additional studies on former residents of the base; and identifies scientific considerations that could help the U.S. Department of the Navy, under which the Marine Corps operates, set priorities on future actions. The report will be released at a 90-minute public briefing.
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New Support For A Controversial Mechanism Underlying An Irregular Heart Beat

The most common form of human heart beat irregularity (atrial fibrillation) can be fatal if left untreated. It has been suggested that it is caused, in part, by calcium leaking from a cellular store in heart cells, potentially through the RyR2 channel, although this mechanism remains controversial. However, a team of researchers at Baylor College of Medicine, Houston, and Dresden University of Technology, Germany, has provided support for this hypothesis by showing that the protein CaMKII can enhance RyR2-mediated calcium leak, promoting atrial fibrillation in mice. The team, led by Xander Wehrens and Dobromir Dobrev, studied mice engineered to express a mutant form of RyR2 associated with calcium leak. Although these mice did not spontaneously develop atrial fibrillation, they were more likely to develop atrial fibrillation than normal mice if their heart rate was forced up. This was related to the functional interaction of CaMKII with RyR2, and blocking CaMKII function in these mice prevented them from developing atrial fibrillation when their heart rate was forced up. As a functional link between CaMKII and RyR2 was observed in heart biopsies from patients with chronic atrial fibrillation, the authors suggest that enhanced CaMKII function might increase calcium leakage via RyR2 and initiate clinical atrial fibrillation. TITLE: Calmodulin kinase II - mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice AUTHORS: Xander H.T. Wehrens Baylor College of Medicine, Houston, Texas, USA. Dobromir Dobrev Dresden University of Technology, Dresden, Germany. View the PDF of this article at: https://www.the-jci.org/article.php?id=37059 Karen Honey Journal of Clinical Investigation JCI online early table of contents: June 15, 2009


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