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Social Smokers: Turning The Tables On Big Tobacco
The tobacco industry knows exactly what makes social smokers tick. Now, researchers want to use that once-secret information to help them quit.
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Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity
Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli.
News of the day
Pregnant Women With H1n1 Flu Should Start Antiviral Treatment As Soon As Possible, While Those Who Are Well Should Be Vaccinated
An Article published Online First (http://www.thelancet.com) and in an upcoming edition of The Lancet shows that pregnant women could be at increased risk for complications from H1N1 flu. Furthermore, the study, from the USA, shows that the rate of hospitalisation for pregnant women is more than four times that of the general population. Pregnant women with H1N1 flu should start antiviral treatment as soon as possible, while those who are well should be vaccinated once a vaccine becomes available. The Article is written by Dr Denise J Jamieson, Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA, and colleagues.
Sexual Health

Must We Keep Depriving Residents Of Sleep?

Before reducing or changing working hours for medical residents in Canada, a thorough evaluation of the impact on the educational experience and acquisition of skills should be conducted, write Dr. Diane Kelsall and the CMAJ editorial team. This will ensure that Canadians will benefit from the skills of a healthy, well-trained resident workforce. Residency agreements are negotiated provincially in Canada and most provinces do not have a maximum work week, meaning residents may work 24 or more continuous hours. Other jobs, such as truck drivers, railway crews and pilots have regulated maximum work hours and rest periods. Medical residents are at increased risk of making medical errors, getting into car accidents or jabbing themselves with a needle after working long shifts. Changes in the US and Europe designed to reduce working hours for residents helped improve quality of life for them, although educational satisfaction remained neutral or even dropped. As workloads shift from residents, staff doctors in many hospitals have experienced increased stress and more work. Some institutions have created non-teaching wards and have hired staff such as nurse practitioners and physician assistants to augment or replace residents. However, "those who believed that patient safety would be greatly improved by well-rested residents have been disappointed" write the authors. "Patient adverse events are usually multi-factorial in origin, and resident fatigue is only one component." The benefits of happier, healthier residents with a more humane work-life balance is reason enough to look at adjusting or reducing resident duty hours. Canadian Medical Association Journal


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