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Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity
Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli.
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CareFusion Expands Pyxis(R) Perioperative Solutions Offering
CareFusion Corporation, the company that will become publicly traded following the planned spinoff of the clinical and medical products businesses of Cardinal Health, announced it has expanded its Pyxis® perioperative offerings that integrate with leading operating room information systems (ORIS), incorporate radio-frequency identification (RFID) technology1 and include new services.
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Healthy Workers Could Get Bigger Insurance Breaks
A health care reform proposal that would allow employers and insurers to give large discounts to employees who lose weight or lower their cholesterol is facing push back from several groups worried about premium disparities, Kaiser Health News reports.
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Minnesota Delegation Wary Of Proposed Health Care Reform

"Here"s a little secret you might not know about the health care reform being debated in Washington: Minnesota might not want it," Minnesota Public Radio reports. The state"s congressional delegation is "not sure that the potential cures for the system - requiring everyone to have insurance, expanding Medicare or taxing health benefits - won"t be worse than what currently ails health care." Rep. Collin Peterson, D-Minn., is critical of the additional taxes proposed to help pay for the overhaul. "What they"re talking about doing here is just adding some more gasoline to the fire that"s going to burn down this country. And I"m not going to go along with that," Peterson says. "Most members of Minnesota"s delegation think some kind of health mandate is a good idea," but they "agree" that a public option in the Medicare model is "a bad deal for the state. The Mayo Clinic, for instance, provides world-class care, but gets half the Medicare payments doctors get in Miami. Democratic Sen. Amy Klobuchar said that"s because Medicare pays for what doctors do, not how well it works." Rep. Michele Bachman, R-Minn., agrees with Klobuchar and "said Medicare sets a bad precedent and that it needs to be fixed first ... So while Minnesotans in Congress say something needs to be done about health care, they"re leery that changes will look too much like existing federal programs" (Nelson, 7/14). This information was reprinted from kaiserhealthnews.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Health Policy Report, search the archives and sign up for email delivery at kaiserhealthnews.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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