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Sensitivity To NNKOAc Is Associated With Renal Cancer Risk
UroToday.com - Cigarette smoking is a major risk factor for renal cell carcinoma (RCC). Cigarette smoke contains a variety of carcinogenic chemicals such as polycyclic aromatic hydrocarbons, aromatic amines, heterocyclic aromatic amines and N-nitrosamines. Among the N-nitrosamines present in cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and the most potent in terms of carcinogenicity.
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Ex-Senate Leaders Craft Bipartisan Health Care Compromise
"Democrats Tom Daschle and George Mitchell are set to join Republicans Bob Dole and Howard Baker on Wednesday to release a $1.2 trillion proposal that would be fully paid for with a combination of spending cuts and tax increases," the Associated Press reports. The proposal from the four former Senate leaders "combines ideas from both political parties to guarantee coverage for all" and is an attempt to "prevent a repeat of the 1990s standoff over health care."
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They Are Young And Need The Job: A Second Chance For Dangerous T Cells
The immune system"s T-cells react to foreign protein fragments and therefore are crucial to combating viruses and bacteria. Errant cells that attack the body"s own material are in most cases driven to cell death. Some of these autoreactive T-cells, however, undergo a kind of reeducation to become "regulatory T-cells" that keep other autoreactive T-cells under control. A group led by immunologist Professor Ludger Klein of LMU Munich has now shown that the developmental stage of an autoreactive T-cell is decisive to its ultimate destiny. Young autoreactive T-cells are very readily reeducated into regulatory T-cells. Under identical conditions, however, older T-cells become fully activated and can cause damage - they are in a way resistant to reeducation. "We now intend to study at the molecular level what makes a T-cell accessible for reeducation," said Klein, "because then it may be possible to convert even normal adult T-cells, which can be obtained easily and in great numbers from blood. Possibly, they could then be used as regulatory T-cells in therapies for autoimmune diseases such as type-1 diabetes or multiple sclerosis: these are diseases that are triggered by uncontrolled autoreactive T-cells." (PNAS, 10 June 2009)
Diagnostics

House Passes Spending Bill; Amendment To Block Removal Of Needle Exchange Funding Ban Defeated

The House on Friday passed a $730.5 billion bill (HR 3293) "to fund health, education and labor programs in fiscal 2010 after narrowly defeating an attempt to strip language that would lift the ban on federal needle exchange programs," in the U.S., CQ Today reports (Wolfe, 7/24). Lawmakers voted 211-218 to reject an amendment by Mark Souder (R-Ind.) that sought to keep the ban in place, the AP/Lewiston Sun Journal reports (Taylor, 7/25). The bill that passed includes a restriction against using federal funds for needle exchanges within 1,000 feet of day care centers, schools, parks, playgrounds, pools and youth centers, the Washington Post reports. Ronald Johnson, deputy executive director of the Washington, D.C.,-based advocacy group AIDS Action, said, "This is the first time in over 20 years that we are on the verge of recognition by the federal government of the proven cost-effectiveness and impact of syringe exchange as a very important tool for prevention of HIV infection and viral hepatitis," adding, "Allowing the local community to use federal funds is very critical to stopping these epidemics" (Fears, 7/25). The bill also drops funding for abstinence-only sex education and "would provide $114 million for a new teenage pregnancy prevention initiative," the Sun Journal article states (7/25). This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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