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UCB And Biogen Idec Discontinue Phase II Clinical Trial Of CDP323 - Analysis Showed No Clinically Relevant Benefit For Patients
UCB and Biogen Idec announced today the discontinuation of the Phase II clinical trial of CDP323 for the treatment of relapsing multiple sclerosis (MS). Preliminary interim efficacy analysis showed that patients enrolled in this clinical trial did not benefit as expected from CDP323 compared to placebo after a six month treatment period. No cases of PML (progressive multifocal leukoencephalopathy) were noted.
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Terry O'Neill Elected New "National Organization for Women" President
The National Organization for Women on Saturday during its annual conference elected Terry O"Neill as the group"s new president, the Indianapolis Star reports. O"Neill succeeds Kim Gandy, who has served two four-year terms as NOW president. The group has grown to include about 500,000 advocate members since its founding in 1966.During the conference, participants discussed a number of women"s rights issues, including same-sex marriage, equal pay and health insurance affordability. O"Neill raised the issue of "conscience" clauses, which allow health care workers to refuse to provide information or services on moral or religious grounds. O"Neill said, "Conscience clauses, where pharmacists refuse birth control sales because it"s against their conscience, must go. Guess what? Women have a constitutional right to birth control," adding, "There is no constitutional right to be a pharmacist" (Jacobs, Indianapolis Star, 6/21).O"Neill served as NOW"s vice president for membership from 2001 to 2005. She most recently served as chief of staff for a county council member in Montgomery County, Md. O"Neill in a prepared statement said that she is "honored and eager" to lead NOW (AP/Google.com, 6/21).
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New Data Support Use Of Simple Test To Predict Endometrial Cancer Response To Chemotherapy
New data presented at the 2009 American Society of Clinical Oncologist (ASCO) Annual Meeting support the use of a laboratory test, ChemoFX(R), to help physicians predetermine the effectiveness of chemotherapy in treating a woman"s endometrial cancer. Investigators found a significant correlation between the test results from 405 patient specimens analyzed using ChemoFx and published patient response rates for each chemotherapeutic regimen, suggesting less effective therapies could be eliminated prior to patient administration. Endometrial cancer is the most common gynecologic cancer among women in the United States.
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Expression Of Myoglobin In Human Cancers

A group led by Dr. Alberto Bardelli at The University of Turin Medical School reports that myoglobin may protect against the stresses of tumor growth. This study can be found in the July 2009 issue of the American Journal of Pathology. Myoglobin plays an important role in muscle cells by both transporting oxygen and preventing cell damage by scavenging free radicals. Tumor cells often survive in hypoxic (low oxygen), high free radical environments, despite these stresses on tumor growth. Flonta et al hypothesized that certain cancers may express myoglobin to survive the conditions associated with tumor growth. Indeed, human epithelial tumors, including breast, lung, ovary, and colon carcinomas, expressed high levels of myoglobin at early stages of development. In addition, myoglobin was induced in cell lines subjected to hypoxia, oxidative stress, and mitogenic stimulation. Myoglobin expression in carcinomas may therefore protect against the stresses of tumor growth. Dr. Bardelli and colleagues postulate that "should myoglobin prove to play a causative role in tumor progression, ò€¦ it is tempting to speculate that targeting one or more of its multiple functions by pharmacological agents or more advanced molecular tools could represent a novel therapeutic strategy in oncology." Flonta SE, Arena S, Pisacane A, Michieli P, Bardelli A: Expression and Functional Regulation of Myoglobin in Epithelial Cancers. Am J Pathol 2009, 174: 2611-2616 Angela Colmone American Journal of Pathology


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