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Rep. Pitts To Offer Amendment Excluding Abortion Coverage From House Health Care Bill
Rep. Joe Pitts (R-Pa.) said he plans to introduce an amendment to the House health care overhaul bill (HR 3200) that would prohibit insurers from being required to cover abortion, unless the woman"s life is at risk or the pregnancy is a result of rape or incest, CQ Today reports. Pitts said he will offer the amendment Thursday at the first House Energy and Commerce Committee mark-up session.The House bill would authorize the Obama administration to craft minimum benefit standards for health insurance plans, CQ Today reports. President Obama has said that he considers reproductive health care an essential service. Democrats say Republicans are trying to expand the Hyde amendment"s exclusion on using federal Medicaid funding to cover abortion to all health care services. Rep. Diana DeGette (D-Colo.), vice chair of the Energy and Commerce Committee, said, "I think that if anti-choice Republicans or others see this as an opportunity to expand prohibitions on a legally allowed and medically appropriate practice, then they are wrong." She added, "We are not going to use the health care bill to expand prohibitions on a legal medical practice, period." Pitts, Rep. Christopher Smith (R-N.J.) and other supporters of the amendment say it is necessary to block the administration from requiring abortion coverage. The committee has blocked three of Smith"s abortion-related amendments so far this year (Wayne, CQ Today, 7/15).
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Lawmakers Seek Price Tag They Can Agree On
"Lawmakers working to overhaul the U.S. health-care system face a pressure-filled July after leaving town this week without resolving the biggest questions dividing Democrats and Republicans," Bloomberg reports. Democrats on the Senate Finance Committee - which observers deem most likely to come up with a passable, bipartisan bill - have been working to reduce the cost of the overhaul to gain Republican support, but had not yet released a proposal. Bloomberg adds: "While the Congressional Budget Office said options under consideration by the committee can keep the cost within Baucus"s goal of $1 trillion over 10 years, how to pay for the plan remains unsettled. So is structuring some kind of government-run competition for insurers. ... "Nothing has been set," Montana Democrat [Max] Baucus told reporters in the Capitol on June 25. The recess offers a chance for "taking stock," he said" (Jensen and Livkin, 6/29).
Diagnostics

Enzyme-Equipped Liposomes Embedded In Polymer Capsules As A Novel Biomedical Transport System

When cells cannot carry out the tasks required of them by our bodies, the result is disease. Nanobiotechnology researchers are looking for ways to allow synthetic systems take over simple cellular activities when they are absent from the cell. This requires transport systems that can encapsulate medications and other substances and release them in a controlled fashion at the right moment. The transporter must be able to interact with the surroundings in order to receive the signal to unload its cargo. A team led by Frank Caruso at the University of Melbourne has now developed a microcontainer that can hold thousands of individual "carrier units" - a "capsosome". As they report in the journal Angewandte Chemie, these are polymer capsules in which liposomes have been embedded to form subcompartments. Currently, the primary type of nanotransporter used for drugs is the capsule: Polymer capsules form stable containers that are semipermeable, which allows for communication with the surrounding medium. However, these are not suitable for the transport of small molecules because they can escape. Liposomes are good at protecting small drug molecules; however, they are often unstable and impermeable to substances from the environment. The Australian researchers have now combined the advantages of both systems in their capsosomes. Capsosomes are produced by several steps. First, a layer of polymer is deposited onto small silica spheres. This polymer contains building blocks modified with cholesterol. Liposomes that have been loaded with an enzyme can be securely anchored to the cholesterol units and thus attached to the polymer film. Subsequently, more polymer layers are added and then cross-linked by disulfide bridges into a gel by means of a specially developed, very gentle cross-linking reaction. In the final step, the silica core is etched away without damaging the sensitive cargo. Experiments with an enzyme as model cargo demonstrated that the liposomes remain intact and the cargo does not escape. Addition of a detergent releases the enzyme in a functional state. By means of the enzymatic reaction, which causes a color change of the solution, it was possible to determine the number of liposome compartments to be about 8000 per polymer capsule. "Because the capsosomes are biodegradable and nontoxic", says Brigitte Staedler, a senior researcher in the group, "they would also be suitable for use as resorbable synthetic cell organelles and for the transport of drugs." In addition, the scientists are planning to encapsulate liposomes filled with different enzymes together and to equip them with specific "receivers" which would allow the individual cargo to be released in a targeted fashion. This would make it possible to use enzymatic reaction cascades for catalytic reaction processes. Author: Frank Caruso, University of Melbourne (Australia) Title: A Microreactor with Thousands of Subcompartments: Enzyme-Loaded Liposomes within Polymer Capsules Angewandte Chemie International Edition 2009, 48, No. 24, 4359-4362, doi: 10.1002/anie.200900386 Frank Caruso Wiley-Blackwell


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