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Array BioPharma Advances Its Lead MEK Inhibitor Into Cancer
Array BioPharma Inc. (NASDAQ: ARRY) announced the filing of an investigational new drug (IND) application with the U.S. Food and Drug Administration to initiate a Phase 1 clinical trial in cancer patients with its most advanced wholly owned MEK inhibitor, ARRY-162. Recent research confirms that the MEK pathway acts as a central axis in the proliferation of different tumors including melanoma, non-small cell lung, head/neck and pancreatic cancers. Array plans to simultaneously develop ARRY-162 for the treatment of both cancer and inflammatory disease. Array is currently completing a worldwide Phase 2, double-blinded clinical trial with ARRY-162 in 200 patients with active rheumatoid arthritis.
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Angina: Risk Of Heart Attack And Death Doubles In Men
A study just published on bmj.com reports that the risk of heart attack is multiplied by two for men who have angina. Also their risk of suffering a heart disease-related death is three times higher than for women with the same condition.
News of the day
Obama's Notre Dame Speech Strikes 'Forceful Blow' Against Culture Wars, Washington Post Opinion Piece Says
President Obama during his speech at Notre Dame, "fought back" antiabortion-rights protesters "not with harsh words but with the most devastating weapons in his political arsenal: a call for "open hearts," "open minds," "fair-minded words" and a search for "common ground,"" Washington Post columnist E.J. Dionne writes. Dionne continues that as "Obama"s opponents seek to reignite the culture wars," the president has "refused to join" and instead "opted for humility." Dionne writes that Obama "did all this without skirting the abortion question and without flinching from the "controversy surrounding my visit here."" In what might have been Obama"s "most radical and the most conservative speech of his presidency," he "[a]cknowledg[ed] the Roman Catholic Church"s role in supporting his early community organizing work," while drawing "on the res of Catholic social thought" that "combines opposition to abortion with a sharp critique of economic injustice and thus doesn"t squeeze into the round holes of contemporary ideology," according to Dionne.In his speech, Obama "tried to undo mistakes made early in his administration, making clearer, for example, that his revisions of an earlier Bush executive order on the rights of health professionals would continue to "honor the conscience of those who disagree with abortion,"" Dionne continues. In addition, Obama "paid more respect to opponents of stem cell research -- he spoke of their "admirable conviction about the sacredness of life" -- than he had in his original announcement altering Bush"s policies," Dionne writes. He adds that on the issue of abortion rights, "Obama endorsed a broad agenda: "Let"s reduce unintended pregnancies. Let"s make adoption more available. Let"s provide care and support for women who do carry their children to term.""However, it "was hard to square that message with the rage directed toward Obama" and Notre Dame"s president, the Rev. John Jenkins, by their opponents, Dionne says. "By facing their arguments head-on and by demonstrating his attentiveness to Catholic concerns, Obama strengthened moderate and liberal forces inside the church itself," according to Dionne. He concludes, "He also struck a forceful blow against those who would keep the nation mired in culture-war politics without end. Obama"s opponents on the Catholic right placed a large bet on his Notre Dame visit. And they lost" (Dionne, Washington Post, 5/18).
Medical Devices

Changing Paradigms In Hereditary Angioedema: Pathophysiology, Diagnosis And Treatment

Hereditary angioedema (HAE) is an autosomal dominant disease affecting between 4,000 and 10,000 people in the United States. HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is important for physicians to understand the diagnostic strategies in HAE as well as the conventional and emerging therapeutic options available for HAE prophylaxis and acute attacks. To address the need for current education on HAE, Robert Michael Educational Institute LLC (RMEI) and Postgraduate Institute for Medicine (PIM) are jointly sponsoring a complimentary continuing education monograph entitled Changing Paradigms in Hereditary Angioedema: Pathophysiology, Diagnosis and Treatment. The content for this monograph was derived from a live symposium which took place on February 13, 2009 in Fort Lauderdale, Florida. This activity is supported by an educational grant from ViroPharma Incorporated and is accredited for physicians. Faculty reviewers include Michael M. Frank, MD from Duke University School of Medicine in Durham, NC; Bruce L. Zuraw, MD from the University of California, San Diego School of Medicine in San Diego, CA; and Marc A. Riedl, MD from the University of California, Los Angeles David Geffen School of Medicine in Los Angeles, CA. "Quality continuing medical education is vital to developing and increasing knowledge and skills and enhancing patient care," says Robert Michael Educational Institute LLC President and CEO, Robert M. Colleluori. RMEI is a medical education company that specializes in independent, certified and non-certified education. The goal of all certified RMEI educational offerings is to promote a spirit of lifelong learning and continuous professional development. RMEI works closely with medical experts to design activities that improve diagnosis and treatment leading to better outcomes for patients. These activities include national and international symposia, teleconferences, live meetings, enduring print materials, and interactive Internet programs. Robert Michael Educational Institute LLC


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