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Changing Paradigms In Hereditary Angioedema: Pathophysiology, Diagnosis And Treatment
Hereditary angioedema (HAE) is an autosomal dominant disease affecting between 4,000 and 10,000 people in the United States. HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is important for physicians to understand the diagnostic strategies in HAE as well as the conventional and emerging therapeutic options available for HAE prophylaxis and acute attacks.
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Limited Data Suggest Possible Association Between Agent Orange Exposure And Ischemic Heart Disease And Parkinson's Disease In Vietnam Veterans
A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinson"s disease for Vietnam veterans. The report is the latest in a congressionally mandated series by the IOM that every two years reviews the evidence about the health effects of these herbicides and a type of dioxin -- TCDD -- that contaminated some of the defoliants.
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Ability To Literally Imagine Oneself In Another's Shoes May Be Tied To Empathy
New research from Vanderbilt University indicates the way our brain handles how we move through space - including being able to imagine literally stepping into someone else"s shoes - may be related to how and why we experience empathy toward others.
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Animal-based Research Key To Medicine Safety

The innovative pharmaceutical industry is committed to ensuring any animal-based research meets the high regulatory standards set by independent ethics committees, Medicines Australia chief executive Ian Chalmers said recently. Mr Chalmers said Medicines Australia member companies are also committed to reducing animal-based research where other methods of laboratory testing are equally effective. "Animal research in Australia can not proceed until it has been scrutinised by appropriate ethics committees and has Government approval," Mr Chalmers said. "This area of research is highly regulated to ensure animal use in research is valid, humane, justifiable and considerate. "Animal-based research is not undertaken lightly. The reality is that it is an essential part of the process that ensures new medicines are adequately safe to test in people. "No regulatory authority would allow patients to take a medicine that had not been appropriately tested on animals to ensure safety and efficacy. If animals were not used in research, there would be far fewer medicines available to patients, nor could their safety be assured. "The industry is constantly striving to discover alternative methods of researching and developing new medicines. Reducing the number of animals that must be used in important tests is a key element in this process. "But we have not yet reached the stage where cell culture work and computers can tell us everything we need to know about how a medicine will behave in the human body. "Until those alternative methods become available, animal use is the only means of gathering vital information for the development of safe and effective medicines." Medicines Australia works closely with the NSW Government on this issue and is represented on the NSW Government"s Animal Research Review Panel. Medicines Australia


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